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Many people have asked the editor about the application of silicon dioxide in the new field of pharmaceutical preparations. Now, let us answer it for you. If you don't know, don't come over yet?
1. Used as a crystal form stability promoter
For instance, research has found that the chemical API of hydroclopidogrel hydrochloride, after being treated with amorphous excipients such as silicon dioxide, has better crystal form reliability and drug compatibility.
2. Used as a grinding aid
Silica dioxide, as a grinding aid, has medicinal value and can promote the crushing and optimization of chemical raw materials, providing a co-research with a high porosity structure for the rapid penetration of moisture.
3. For colon-targeted preparations
Recent studies have shown that the sigmoid colon-targeted drug delivery system software has the advantages of small dosage, high efficacy, low adverse reactions and convenient administration. This traditional Chinese medicine preparation can prevent the drug from being destroyed and degraded during the digestive tract, and immediately dissolves and releases it after reaching the body's blind area, thereby fully exerting the therapeutic effect. Silica dioxide, as a new type of pharmaceutical excipient, has just begun to be used in the traditional Chinese medicine preparations of this drug.
4. It is used in sustained-release preparations
For instance, Zhang Hongmei et al. selected the appropriate dosage of HPMC, MCC, whey protein, sodium dodecyl sulfate, pharmaceutical excipient silica and magnesium stearate based on the release degree and Angle of reversion as indicators, and chose the prescription of lovastatin sustained-release capsules. When the dosage of silica dioxide, a pharmaceutical excipient, is 0.2%, this drug has advantages such as slow drug release and the ability to maintain a long-term blood drug concentration in the body compared with traditional tablet and capsule preparations, providing theoretical significance for the effective utilization of the dissolution rate of lovastatin.
5. Other fields
At present, the pharmaceutical industry has also seen the emergence of silica modified pharmaceutical excipients, which can be classified into two types: self-structure modification and blending modification. If the pharmaceutical excipient silica is produced into mesoporous silica nanoparticles, it can have a tailor-made porosity structure and high surface activity, and can be used as a reasonable drug delivery medium for therapeutic agents. It has significant advantages in the design and transportation of drug packaging.
In addition, the strong adsorption capacity, water absorption, compatibility and surface polymethyl groups of silica, when used as a medium and modified, can be used to produce characteristic biosensors and microbial identification and inspection materials.
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